Tag: anti-anxiety medications

  • Could Anti-Anxiety Meds Be The Next Prescription Drug Epidemic?

    Could Anti-Anxiety Meds Be The Next Prescription Drug Epidemic?

    “We have this whole infrastructure set up to prevent overprescribing of opioids and address the need for addiction treatment. We need to start making benzos part of that.”

    An increase in the number of drug overdose deaths among individuals who used benzodiazepines has some state and local health officials concerned that the drugs could be at the center of a new prescription drug crisis.

    Benzodiazepines, which include such medications as Xanax, Valium and Klonopin, are commonly prescribed for anxiety or insomnia, and in the past two decades-plus, the number of prescriptions written for these medications has risen from 8 million to 14 million adults in the United States. But when taken in combination with prescription or illicit opioids, the likelihood of death can increase as much as tenfold, prompting medical and government officials alike to propose greater attention to their use.

    According to an article in LiveWellNebraska, a joint publication by BlueCross BlueShield Nebraska and the Omaha World-Herald, the number of adults nationwide filling a prescription for benzodiazepines has increased two-thirds between 1996 and 2013—a period of time which, according to the Centers for Disease Control and Prevention (CDC), also saw the sales of prescription opioids quadruple in the U.S. 

    LiveWellNebraska also noted that while prescriptions for benzodiazepines appear to have leveled or declined slightly in the years—and opioid prescriptions have dropped by a fifth since 2013—the level of prescribing for benzodiazepines still remains higher than rates in the mid-1990s.

    Taken on their own or in combination with painkillers, the drugs carry health risks that range from debilitating withdrawal to possible fatality. Research from the CDC found that 23% of individuals who died from an opioid overdose also tested positive for benzodiazepine.

    Reaction from the medical community has been divided between support for benzodiazepines, which have shown to be effective at relieving serious cases of anxiety and insomnia.

    The International Task Force on Benzodiazepines, which counts scientists, researchers and pharmacologists in its number, has formed in response to what has been perceived as backlash against the drugs, despite their potential for positive impact.

    But other health officials and medical professionals have stated that increased focus on the potential health concerns from benzodiazepines may possibly prevent a widespread epidemic like the opioid crisis.

    “We have this whole infrastructure set up now to prevent overprescribing of opioids and address the need for addiction treatment,” said Dr. Anna Lembke, a researcher and addiction specialist at Stanford University. “We need to start making benzos part of that. What we’re seeing is just like what happened with opioids in the 1990s. It really does begin with overprescribing.”

    View the original article at thefix.com

  • Can Combining Opioids And Benzos Increase Overdose Risk?

    Can Combining Opioids And Benzos Increase Overdose Risk?

    The National Institute on Drug Abuse reports that more than 30% of all overdose deaths that involve opioids also involve benzodiazepines.

    When used in combination with opioids, benzodiazepines such as Xanax and Valium can make an individual five times more likely to overdose, a new study published in JAMA Network Open has determined. 

    The study found that benzodiazepines, which are often prescribed for anxiety, can increase the likelihood of overdose when used with opioids, especially in the first 90 days they are used together.

    The National Institute on Drug Abuse (NIDA) reports that more than 30% of all overdose deaths that involve opioids also involve benzodiazepines.

    The new study looked at data from over 71,000 people on Medicare Part D. Researchers divided patients into two groups: those who had taken only opioids prior to overdosing and those who had both opioids and benzodiazepines. Researchers “subdivided [the second group] by the cumulative number of days the patients had taken an opioid with a benzo,” Forbes states.

    The results showed that for individuals taking both forms of medication, overdose risk was five times higher during the first three months when compared to those using only an opioid.

    For the 90 days after the first three months, the risk of overdose doubled. After six months, the risk decreased to the same likelihood as taking only opioids. 

    “Patients who must be prescribed both an opioid and a benzodiazepine should be closely monitored by health care professionals due to an increased risk for overdose, particularly in the early days of this medication regimen,” lead study author Inmaculada Hernandez, assistant professor at the University of Pittsburgh School of Pharmacy, said in a press release.

    2017 study published in the BMJ found that from 2001 to 2013, simultaneous opioid and benzodiazepine prescriptions in 315,000 privately insured patients increased by 80%. 

    As such, one of the factors that researchers considered was the number of clinicians involved with a patient. They found that the more clinicians there were prescribing drugs to a single patient, the greater the risk of overdose.

    “These findings demonstrate that fragmented care plays a role in the inappropriate use of opioids, and having multiple prescribers who are not in communication increases the risk for overdose,” said senior study author Yuting Zhang, PhD, of the University of Pittsburgh Graduate School of Public Health, according to Forbes.

    This study is not the only one of its kind, as the relationship between opioids and benzodiazepines and the associated risks has been studied previously.

    Additionally, earlier in 2018, the FDA published a warning about the potential for respiratory depression issues when taking both medications together, since both depress the central nervous system.

    View the original article at thefix.com