Tag: cbd study

  • Can CBD Help With Meth, Cocaine Addiction?

    Can CBD Help With Meth, Cocaine Addiction?

    Researchers examined whether CBD has the potential to treat meth and cocaine addiction.

    CBD could help treat methamphetamine and cocaine addictions, for which there are currently no medication-assisted treatment options, according to a study released earlier this month. 

    The study, published in the journal Molecules, found that CBD helped reduce cocaine and methamphetamine use in rodents, and lowered their risk of relapse after a period of sobriety. The study authors say that the findings indicate that CBD should be explored as a treatment option for humans. 

    “While preliminary, there is some preclinical evidence showing that treatment with CBD might promote resilience to developing cocaine and meth use disorders and might prevent relapse into drug use after a period of abstinence,” the study authors wrote, according to Marijuana Moment.  

    Other Studies

    Studies have shown that mice that are given higher doses of CBD are less likely to continue seeking out cocaine or methamphetamine. After 14 days without meth or cocaine, mice that were given CBD over an extended time period were less likely to relapse. 

    “A limited number of preclinical studies indicate that CBD could have therapeutic properties on cocaine and meth addiction and some preliminary data suggest that CBD may be beneficial in cocaine-crack addiction in humans,” the study authors wrote. “CBD has shown promising results in reducing the inflammation and seizures induced by cocaine and in several preclinical models of addiction to amphetamine, cocaine and meth. Importantly, a brief treatment of CBD induces a long-lasting prevention of reinstatement of cocaine and meth-seeking behaviors.”

    While medication-assisted treatment for opioid use disorder has become the standard of care, there is currently no option for treating cocaine or meth addiction with medication. 

    “We’re realizing that we don’t have everything we might wish we had to address these different kinds of drugs,” psychiatrist Margaret Jarvis, a distinguished fellow of the American Society of Addiction Medicine, said earlier this year

    This isn’t the first time a study has indicated that CBD has potential for treating addiction. Last year a study also found that rats who received CBD were less likely to administer cocaine or alcohol, even when they were cued to take the substances. 

    Researcher Yasmin Hurd, director of the Addiction Institute at Mount Sinai School of Medicine in New York, has studied the potential of CBD for treating addiction. 

    “When we started investigating CBD, we hypothesized that perhaps it could decrease drug-taking behavior, but instead we saw that it actually decreased craving,” she said last year. “It was very specific about what it decreased, and that was surprising. Other researchers have replicated what we found, so we are confident in our results.”

    View the original article at thefix.com

  • CBD Use Linked To Liver Damage

    CBD Use Linked To Liver Damage

    This isn’t the first time that CBD use has been linked to liver disease.

    In recent years, CBD has been hailed as a health product by everyone from hipsters to health professionals, but a new study indicates that taking CBD could have a nasty effect on your liver, much like other drugs that affect the organ.  

    The study, published in the journal Molecules, looked at the effects of CBD on the livers of mice. The mice were given doses that aligned with the human equivalent of the maximum dose of CBD in Epidiolex, the only marijuana-based medication approved by the FDA.

    The researchers found that CBD quickly had a detrimental effect on the mice’s liver. In addition, the way that the compound affected the mice indicated that it could have dangerous interactions with other drugs. 

    “CBD exhibited clear signs of hepatotoxicity, possibly of a cholestatic nature,” study authors wrote. “The involvement of numerous pathways associated with lipid and xenobiotic metabolism raises serious concerns about potential drug interactions as well as the safety of CBD.”

    Speaking with Nutra, lead study author Igor Koturbash said that the results show that more information is needed about the safe use of CBD.

    “I don’t want to say that CBD is bad and we should ban it,” he said. “But in my opinion there is clearly not enough research.”

    This isn’t the first time that CBD use has been linked to liver disease. In fact, the FDA requires Epidiolex to carry a warning about liver issues, and patients who receive the drug have their livers monitored regularly. Even in the testing phases of the drug, there were indications of adverse liver reactions. 

    “There is a potential for liver injury,” Koturbash said. “If you look at the Epidiolex label, it clearly states a warning for liver injury; it states you have to monitor the liver enzyme levels of the patients. In the clinical trials 5% to 20% of patients developed elevated liver enzymes and some patients were withdrawn from the trials.”

    Koturbash explained that the way that CBD affects the body could also cause a host of other unintended side-effects, including in the way that other drugs are processed. 

    “CBD differentially regulated more than 50 genes, many of which were linked to oxidative stress responses, lipid metabolism pathways and drug metabolizing enzymes,” he said. “There is a potential for herb/drug interactions.”

    In fact, Koturbash has another study about drug and herb interactions with CBD that is pending publication. In the meantime, he cautioned that there is still much to be discovered about CBD. 

    View the original article at thefix.com