Tag: psychoactive drugs

  • 1,000-Year-Old Psychedelic Drug Kit Discovered By Archaeologists

    1,000-Year-Old Psychedelic Drug Kit Discovered By Archaeologists

    The “ritual bundle” contained ayahuasca ingredients and traces of cocaine.

    An ancient ritual bundle recovered in Bolivia shows that people having been using psychoactive drugs for millennia. 

    The bundle contained harmine and dimethyltryptamine (DMT), the two primary ingredients of ayahuasca, according to research published in the Proceedings of the National Academy of Sciences. Ayahuasca, which causes people to hallucinate and vomit, has become a popular drug with spiritual adventurers who extol its supposed health benefits. 

    “Our findings support the idea that people have been using these powerful plants for at least 1,000 years, combining them to go on a psychedelic journey, and that ayahuasca use may have roots in antiquity,” said archaeologist Melanie Miller, of the University of California, Berkeley, who led the team of researchers who analyzed the bundle. 

    “This is the first evidence of ancient South Americans potentially combining different medicinal plants to produce a powerful substance like ayahuasca,” Miller said. 

    In addition to the ingredients in ayahuasca, the bundle also contained traces of cocaine. The bundle, which was made from three fox snouts sewn together, contained spatulas and spoons for snorting drugs. Miller said that it was likely used by a shaman or someone who worked with medicinal plants. The team believes the pouch is from the Tiwanaku, a pre-Inca civilization that “dominated the southern Andean highlands from about 550 to 950 A.D.”

    Miller said the pouch was “the most amazing artifact I’ve had the privilege to work with.”

    She said, “A lot of these plants, if consumed in the wrong dosage, could be very poisonous, so, whoever owned this bundle would need to have had great knowledge and skills about how to use these plants, and how and where to procure them.”

    Miller said that the properties that make ayahuasca popular today likely made it important to the ancients. 

    “The tryptamine DMT produces strong, vivid hallucinations that can last from minutes to an hour, but combined with harmine, you can have prolonged out-of-body altered states of consciousness with altered perceptions of time and of the self,” she said.

    The bundle was initially found in a cave site by archeologists from Bolivia and Pennsylvania State University. Those archeologists contacted Miller to help identify the contents of the bundle and to assist with the final excavation. Because of the altitude where the bundle was found it was in good condition. 

    “We were amazed to see the incredible preservation of these compounds in this ritual bundle,” said Miller. “I feel very lucky to have been a part of this research.”

    View the original article at thefix.com

  • How Octopuses Feel On MDMA

    How Octopuses Feel On MDMA

    A new study revealed some interesting findings about the anti-social, eight-legged invertebrates.  

    While octopuses and humans are separated by more than 500 millions years of evolution, we may share one fascinating similarity—how we respond to MDMA.

    According to new research, published in the journal Current Biology last Thursday (Sept. 20), octopuses exposed to MDMA “tended to spend more time” with other octopuses.

    The results of the study are especially fascinating because these eight-legged animals are naturally asocial, except when mating. Those that were not exposed to MDMA avoided other octopuses.

    As NPR reported, “The researchers knew from previous tests that an octopus would normally stay far, far away from a second octopus that was confined to a small cage inside the first one’s tank. But an octopus on MDMA would get up-close and personal with the new neighbor.”

    Gül Dölen, assistant professor of neuroscience at Johns Hopkins University School of Medicine, conducted the experiment after finding a striking similarity in how serotonin binds to brain cells in octopuses and humans while analyzing the genetic code of the California two-spot octopus.

    MDMA was administered to the octopuses by placing the invertebrates in a beaker of seawater with the drug, that was absorbed through the gills.

    They started them off at a high dose, to see how they would react. “They really didn’t like it. They looked like they were freaked out,” said Dölen. “They were just taking these postures of super hypervigilance. They would sit in the corner of the tank and stare at everything.”

    The animals reacted much differently when given a lower dose.

    “After MDMA, they were essentially hugging. [They were] really just much more relaxed in posture, and using a lot more of their body to interact with the other octopus,” said Dölen.

    Dölen and her colleagues acknowledge that the animals’ lovey-dovey behavior has yet to be affirmed. Another neuroscientist who was not involved in the study asked, “Is it really affection? How would we know? It’s totally fascinating and super-suggestive, but I am not 100% convinced that this is doing the same thing in octopus and in human.”

    He added, “It just shows us how much we don’t know and how much there is out there to understand.”

    View the original article at thefix.com