Tag: Narcan

  • Pandemic Presents New Hurdles, and Hope, for People Struggling with Addiction

    “There’s social distancing — to a limit…I think when someone’s life is in jeopardy, they’re worth saving. You just can’t watch people die.”

    Before Philadelphia shut down to slow the spread of the coronavirus, Ed had a routine: most mornings he would head to a nearby McDonald’s to brush his teeth, wash his face and — when he had the money — buy a cup of coffee. He would bounce between homeless shelters and try to get a shower. But since businesses closed and many shelters stopped taking new admissions, Ed has been mostly shut off from that routine.

    He’s still living on the streets.

    “I’ll be honest, I don’t really sleep too much,” said Ed, who’s 51 and struggling with addiction. “Every four or five days I get a couple hours.”

    KHN agreed not to use his last name because he uses illegal drugs.

    Philadelphia has the highest overdose rate of any big city in America — in 2019, more than three people a day died of drug overdoses there, on average. Before the coronavirus began spreading across the United States, the opioid overdose epidemic was the biggest health crisis on the minds of many city officials and public health experts. The coronavirus pandemic has largely eclipsed the conversation around the opioid crisis. But the crisis still rages on despite business closures, the cancellation of in-person treatment appointments and the strain on many addiction resources in the city.

    When his usual shelter wasn’t an option anymore, Ed tried to get into residential drug treatment. He figured that would be a good way to try to get back on his feet and, if nothing else, get a few good nights of rest. But he had contracted pinkeye, a symptom thought to be associated with the virus that leads to COVID-19, so the evaluation center didn’t want to place him in an inpatient facility until he’d gotten the pinkeye checked out. But he couldn’t see a doctor because he didn’t have a phone for a telehealth appointment.

    “I got myself stuck, and I’m trying to pull everything back together before it totally blows up,” he said.

    Rosalind Pichardo wants to help people in Ed’s situation. Before the pandemic, Pichardo would hit the streets of her neighborhood, Kensington, which has the highest drug overdose rate in Philadelphia. She’d head out with a bag full of snack bars, cookies and Narcan, the opioid overdose reversal drug.

    She’d hand Narcan out to people using drugs, and people selling drugs — anyone who wanted it. Pichardo started her own organization, Operation Save Our City, which initially set out to work with survivors of gun violence in the neighborhood. When she realized that overdoses were killing people too, she began getting more involved with the harm reduction movement and started handing out Narcan through the city’s syringe exchange.

    When Pennsylvania’s stay-at-home order went into effect, Pichardo and others worried that more people might start using drugs alone, and that fewer first responders would be patrolling the streets or nearby and able to revive them if they overdosed.

    So, Pichardo and other harm reduction activists gave out even more Narcan. A representative for Prevention Point Philadelphia, the group that operates a large syringe exchange program in the city, said that during the first month of the city’s stay-at-home order, they handed out almost twice as much Narcan as usual.

    After the lockdowns and social distancing began, Pichardo worried that more people would be using drugs alone, leading to more overdoses. But Philadelphia’s fatal overdose rate during the pandemic remains about the same as it was this time last year. Pichardo said she thinks that’s evidence that flooding the streets with Narcan is working — that people are continuing to use drugs, and maybe even using more drugs, but that users are utilizing Narcan more often and administering it to one another.

    That is the hope. But Pichardo said users don’t always have a buddy to keep watch, and during the pandemic first responders have seemed much more hesitant to intervene. For example, she recently administered Narcan to three people in Kensington who overdosed near a subway station, while two police officers stood by and watched. Before the pandemic, they would often be right there with her, helping.

    To reverse the overdoses, Pichardo crouched over the people who she said had started turning blue as their oxygen levels dropped. She injected the Narcan into their noses, using a disposable plastic applicator. Normally, she would perform rescue breathing, too, but since the pandemic began she has started carrying an Ambu bag, which pumps air into a person’s lungs and avoids mouth-to-mouth resuscitation. Among the three people, she said, it took six doses of Narcan to revive them. The police officers didn’t step in to help but did toss several overdose-reversal doses toward Pichardo as she worked.

    “I don’t expect ’em to give ’em rescue breaths if they don’t want to, but at least administer the lifesaving drug,” Pichardo said.

    In her work as a volunteer, she has reversed almost 400 overdoses, she estimated.

    “There’s social distancing — to a limit,” Pichardo said, “I think when someone’s life is in jeopardy, they’re worth saving. You just can’t watch people die.”

    Even before Philadelphia officially issued its stay-at-home order, city police announced they would stop making low-level arrests, including for narcotics. The idea was to reduce contact overall, help keep the jail population low and reduce the risk of the virus getting passed around inside. But Pichardo and other community activists said the decreased law enforcement emboldened drug dealers in the Kensington neighborhood, where open-air drug sales and use are common.

    “You can tell they have everything down pat, from the lookout to the corner boys to the one actually holding the product — the one holding the product’s got some good PPE gear,” said Pichardo.

    More dealers working openly on the street has led to more fights over territory, she added, which in turn has meant more violence. While overall crime in Philadelphia and other major cities has declined during the pandemic, gun violence has spiked.

    Police resumed arrests at the beginning of May.

    Now when she goes out to offer relief and hand out Narcan, Pichardo packs a few extra things in her bag of supplies: face masks, gloves and gun locks.

    “It’s like the survival kit of the ’hood,” she said.

    For those struggling with addiction who are ready to start recovery, newly relaxed federal restrictions have made it easier to get medications that curb opioid cravings and stem withdrawal. Several efforts are underway among Philadelphia-based public health groups and criminal justice advocacy organizations to give cellphones to people who are homeless or coming out of jail, so they can make a telehealth appointment and get quicker access to a prescription for those medicines.

    During the pandemic, people taking medication-assisted treatment can renew their prescription every month instead of every week, which helps decrease trips to the pharmacy. It is too soon to know if more people are taking advantage of the new rules, and accessing medication-assisted treatment via telehealth, but if that turns out to be the case, many addiction medicine specialists argue the new rules should become permanent, even after the pandemic ends.

    “If we find that these relaxed restrictions are bringing more people to the table, that presents enormous ethical questions about whether or not the DEA should reinstate these restrictive policies that they had going in the first place,” said Dr. Ben Cocchiaro, a physician who treats people with substance-use disorder.

    Cocchiaro said the whole point of addiction treatment is to facilitate help as soon as someone is ready for it. He hopes if access to recovery can be made simpler during a pandemic, it can remain that way afterward.

    This story is part of a partnership that includes WHYY, NPR and Kaiser Health News.

    View the original article at thefix.com

  • Should Narcan Training Be The New CPR?

    Should Narcan Training Be The New CPR?

    “Who should carry Narcan? The same people who should carry an EpiPen: anyone who’s around someone who might need it. And, in today’s opioid crisis, that’s nearly everyone.”

    Each year, 12 million Americans are trained to deliver lifesaving CPR. Vastly fewer are trained to use the opioid overdose reversing drug, Narcan. 

    Dr. Mark Calarco, national medical director for clinical diagnostics of American Addiction Centers, says that we need to make Narcan training the new CPR, getting more people to carry the lifesaving drug and administer it in emergencies. 

    “With tens of thousands of American lives lost each year to drug overdose, it’s critical that we begin training Americans to administer Narcan (naloxone), just as we did with CPR, to help save the lives of our neighbors, family members and friends,” Calarco writes for MedCity News.

    Surgeon General Wants All Americans To Carry Narcan

    In April, Surgeon General Jerome Adams called on all Americans to carry Narcan and learn how to use it. 

    “We should think of naloxone like an EpiPen or CPR. Unfortunately, over half of the overdoses that are occurring are occurring in homes, so we want everyone to be armed to respond,” Adams told NPR at the time

    Stigma Persists

    And yet, stigma against mental illness and addiction has kept this from happening, Calarco writes. 

    “While there’s some controversy over making Narcan so readily and widely available, the reluctance is based mostly on the stigma associated with addiction and mental health issues, and an overall lack of understanding about how addiction impacts an individual and the community. The truth is, addiction and overdose can affect anyone. It doesn’t discriminate based on income, gender, ethnicity, or background,” he writes.

    While Calarco says he would “encourage everyone to take a CPR course,” he noted that CPR is physically taxing and difficult to learn, and 45% of people who need it will die from their condition anyway. 

    “In contrast, administering naloxone (Narcan) is relatively easy for non-medical personnel, and giving it quickly after an opioid overdose rapidly reverses respiratory depression—the primary cause of death. It is extremely safe, effective, and works in seconds,” Calarco writes. 

    Forty-nine states allow anyone to carry and administer Narcan. In most areas, getting trained is as simple as going to your pharmacy, asking for a kit (which is usually covered by insurance) and listening to the pharmacist for a few minutes. This is a step everyone should take, Calarco writes.

    Saving Lives

    “Who exactly should carry Narcan? The same people who should carry an EpiPen: anyone who’s around someone who might need it. And, in today’s opioid crisis, that’s nearly everyone.”

    Taking this small step could be lifesaving, he writes. 

    “Carry it with you at all times and hope you never have to use it,” Calarco writes. “But know that you could be the difference between life and death for someone if you do.”

    View the original article at thefix.com

  • Improvised Nasal Naloxone Devices Less Effective Than Narcan, Study Finds

    Improvised Nasal Naloxone Devices Less Effective Than Narcan, Study Finds

    The FDA-approved Narcan nasal spray delivers more of the antidote into the blood than the improvised naloxone device

    A recent study conducted by the National Institute on Drug Abuse (NIDA) found that improvised nasal naloxone devices (INNDs) are significantly less effective at administering high enough doses of the overdose-reversing medication than the FDA-approved Narcan.

    Naloxone is the drug that can reverse opioid overdoses that kill tens of thousands of people in the U.S. every year. Efforts to make it available, particularly in the form of Narcan, are a part of the national fight against the deadly opioid epidemic.

    INNDs, according to Psych Congress, “consisting of a prefilled naloxone syringe attached to a mucosal atomization device” and have been used by first responders and others to successfully reverse overdoses for 25 years.

    However, the study, first reported on by NIDA on March 15, found that Narcan does a better job of delivering high enough doses of naloxone to be maximally effective. 

    “Scientists found that the approved naloxone devices deliver higher blood levels of naloxone than the improvised nasal devices,” the report reads. “In fact, levels in the plasma concentration of naloxone are considerably lower when improvised devices are used. The FDA-approved 4-mg dose nasal spray produced the highest blood level of naloxone of all the products tested.”

    Speed and plasma concentration of naloxone are especially important as overdoses of the highly potent synthetic opioid fentanyl have skyrocketed in the past few years. Data from the Centers for Disease Control and Prevention (CDC) found that fentanyl-related overdose deaths doubled each year from 2013 to 2016.

    The fastest way to administer naloxone to counter an opioid overdose is with an IV, but first responders might not have access to the equipment they need to give a naloxone IV when time is of the essence.

    Narcan is a simple nasal spray that does not require assembly and can be administered in one nostril while the patient is lying on their back. Members of the public, including people with opioid use disorders, can be easily trained to administer Narcan, and it is available to anyone without a prescription. Health insurance may even cover some or all of the cost.

    “Using the FDA-approved nasal Narcan spray is a great choice for average consumers, who will likely keep only one or two devices on hand,” said NIDA’s Dr. Philip A. Krieter. “It is smaller, easier to use, and doesn’t require much if any training to use properly. The Narcan spray is a ready-to-use device; the improvised device needs assembly, and lay persons may not able to use it correctly in a panic situation.”

    However, according to TIME, a Narcan kit with two doses costs around $135 without insurance, which may be prohibitively expensive for some.

    Another option is the auto-injection device Ezvio, which has also been approved by the FDA. According to Dr. Krieter, a generic version of Ezvio will become available “later this year for some purchasers.”

    View the original article at thefix.com

  • California Jail Guards Get Narcan After Possible Fentanyl Exposure

    California Jail Guards Get Narcan After Possible Fentanyl Exposure

    This is not the first time that an officer has been hospitalized or received Narcan after being exposed to fentanyl.

    Two guards at a California jail were given Narcan and taken to the hospital after they began showing symptoms of opioid exposure. 

    According to SF Gate, guards at Santa Rita Jail in Dublin searched a woman who was being booked in the jail. They found a black substance on the woman, but could not identify the drug. They examined it closely trying to discern what type of drug it was, while wearing gloves. 

    However, after the examination was complete, one officer began feeling sick and showing signs of confusion. Soon after, the other officer complained of sickness as well. The staff at the jail suspected that the pair had been exposed to an opioid, and administered Narcan before transporting them to the hospital. 

    First responders and law enforcement officials have been warned about the dangers of accidental fentanyl overdose, and this is not the first time that an officer has been hospitalized or received Narcan after being exposed to the drugs. 

    “The presence of [synthetic opioids] poses a significant threat to first responders and law enforcement personnel who may come in contact with this substance. In any situation where any fentanyl-related substance, such as carfentanil, might be present, law enforcement should carefully follow safety protocols to avoid accidental exposure,” the Drug Enforcement Administration said in an officer safety alert issued last year

    However, some research indicates that it is unlikely that first responders or others could accidentally overdose on even the most powerful synthetic opioids by touching the substance. 

    “I would say it’s extraordinarily improbable that a first responder would be poisoned by an ultra-potent opioid,” Dr. David Juurlink, a researcher at Sunnybrook Health Sciences Centre, told The New York Times. “I don’t say it can’t happen. But for it to happen would require extraordinary circumstances, and those extraordinary circumstances would be very hard to achieve.”

    According to Vox, reports have shown that fentanyl is not easily absorbed through the skin, so accidental overdose is very unlikely. In one video by harm reduction advocate Chad Sabora, he tries to dispel this myth

    Some people believe that the reports of first responders being harmed by exposure to synthetic opioids can trigger a type of placebo effect. That may have been the case with Scottie Wightman, a Kentucky emergency medical technician who became unresponsive after one call. Wightman was treated with Narcan and was seemingly revived, but drug tests later showed there were no drugs in his system. 

    Jeremy S. Faust, an emergency room doctor in Boston, emphasized that first responders shouldn’t let fear of opioid exposure deter the care they give to the public. 

    “I want to tell first responders, Look, you’re safe,” he said. “You can touch these people. You can interact with them. You can go on and do the heroic lifesaving work that you do for anyone else.”

    View the original article at thefix.com

  • "Church of Safe Injection" Hopes to Save Lives Through Needle Exchange

    "Church of Safe Injection" Hopes to Save Lives Through Needle Exchange

    A 26-year-old former drug user turned recovery coach has founded a harm-reduction-based “church” that offers clean needles, Narcan and a welcoming brand of faith-driven dialogue to drug users.

    As the viability of safe injection sites continues to be debated across the globe, a 26-year-old former drug user turned recovery coach has found a following with a harm-reduction-based “church” that offers clean needles, the overdose reversal drug Narcan and a welcoming brand of faith-driven dialogue to drug users.

    As the Huffington Post noted, the tenets of Jesse Harvey’s “Church of Safe Injection” have been taken up by others in eight states, but his efforts have been met with resistance by some law enforcement and health officials who have abided by federal law that prohibits safe injection sites.

    Since late 2018, Harvey, who has been in recovery from drug and alcohol dependency for several years, has been operating his “church” from the back of his car, which he stations near a park frequented by drug users in Lewiston, Maine.

    With the help of volunteers, he offers free needles and a gospel that emphasizes inclusion and support for those in need. That approach informs the Church’s three basic principles: helping those in need, welcoming people of all faiths, as well as atheists, and keeping drug users healthy through harm reduction-based support.

    “Our religious belief is simply that people who use drugs don’t deserve to die,” Harvey told the Huffington Post.

    That philosophy has attracted others, especially those with religious backgrounds who have been dismayed by some traditional churches, which have rejected or condemned drug users.

    To date, 18 Churches of Safe Injection have been established in eight states, and Harvey hopes to incorporate the Church as a nonprofit in order to apply for religious exemption to the Controlled Substances Act so he can open a legal safe injection site.

    However, Harvey’s goals run opposite of many state policies regarding needle exchange and safe injection sites. Maine has only six certified needle exchanges, none of which are located in Lewiston, and the state’s Center for Disease Control issued strict warnings to those exchanges about regulations after Harvey began attracting media attention.

    Eventually, Lewiston police warned him about possible misdemeanor charges for possessing more than 10 syringes at one time, which prompted Harvey to stop handing out clean needles.

    However, as the Post feature noted, he continues to offer Narcan and bags of supplies, including saline, alcohol wipes and rubber ties, to those who meet him in Lewiston. Harvey also hopes to start a drug users’ union in Maine, which would serve as a center for health and safety advocacy. In an op-ed penned for the Portland Press Herald in late 2018, Harvey summed up his goal for the church: “Politicians, law enforcement, and health care haven’t taken the lead here, so our church is.”

    View the original article at thefix.com

  • Maryland Funeral Directors: We're The "Last Responders" To Opioid Crisis

    Maryland Funeral Directors: We're The "Last Responders" To Opioid Crisis

    Funeral directors in the state claim that safety has become an issue when dealing with opioid overdose victims. 

    Proactive funeral directors in Maryland are stocking up on naloxone, the opioid overdose antidote, as they’ve seen a dramatic increase in the number of opioid-related deaths.

    They’re calling themselves the “last responders” to Maryland’s opioid crisis, the Baltimore Sun reports.

    In 2017, the Tri-County Funeral Directors Association launched an awareness campaign in local newspapers to notify communities that “We Don’t Want Your Business” when it comes to opioid abuse.

    “We see a side of this tragic epidemic that many don’t see,” said association president James Schwartz. “The devastation families are facing is heartbreaking.”

    Schwartz tells the Baltimore Sun that other funeral home directors have known not only family members, but funeral home guests “who have come and had either an opioid reaction in the parking lot or other areas during the service time.” 

    “This has caused the folks stress because not only are they grieving this person and now somebody else is having the same tragic result,” Schwartz said.

    The National Funeral Directors Association urges members to protect themselves while handling deceased victims of opioid overdose.

    “Coming into contact with a minuscule dose of fentanyl or carfentanil can be fatal,” the association warns. (This point is oft-repeated, but harm reduction and addiction/recovery advocates say it’s merely a harmful myth.)

    “The opioid crisis presents unique challenges for funeral directors, from working with families whose loved one has died from an overdose to protecting themselves from harm when handling the body of an overdose victim during removal or embalming,” says the funeral directors association.

    In 2017, opioid overdose deaths continued to climb in Maryland, accounting for the majority of drug/alcohol-related deaths—2,009 of 2,282 overdoses were opioid-related, according to the state’s Department of Health.

    “This is an escalating epidemic,” said Baltimore Health Commissioner Dr. Leana Wen, whose city saw the worst of the opioid crisis. “But still we don’t even see the peak of this epidemic yet.”

    In response, Maryland schools and libraries are also stocking up on naloxone. “The rule of thumb is: when in doubt, use it,” said funeral director Jeffrey L. Gair.

    The antidote is there “if there’s ever the need while we’re on duty at the funeral home,” Gair said.

    View the original article at thefix.com

  • Narcan Creator Working On Fentanyl "Antidote"

    Narcan Creator Working On Fentanyl "Antidote"

    The new formulation is reportedly five times stronger than Narcan and will last longer. 

    A stronger formulation of Narcan (naloxone) nasal spray, the opioid overdose antidote, is in the works, FOX Business reports. There’s a need for a stronger antidote, its developers say, to counter the rising use of fentanyl.

    Fentanyl is a synthetic opioid pain reliever said to be 50-100 times more potent than morphine. Though it is a pharmaceutical drug, illicitly-made fentanyl is said to have fueled rising rates of drug overdose deaths in the United States.

    Narcan nasal spray, which reverses opioid overdose, hit the market in early 2016 after receiving fast-track designation by the Food and Drug Administration. Now first responders, health workers, and laypeople across the U.S. are equipped with Narcan—but in some cases, the otherwise life-saving drug is not enough.

    “Narcan is not the 100% fail safe that people may think it is, it does not always work,” warned police officials in West Fargo, North Dakota, responding to the emergence of acryl fentanyl, a newer, stronger fentanyl analog, last year. These illicitly-made opioids may require multiple doses of Narcan.

    Roger Crystal, the creator of Narcan and CEO of Opiant Pharmaceuticals, is now working with the government to create a new opioid overdose antidote that will match the strength of increasingly potent fentanyl analogs.

    The new formulation, Nasal Nalmefene, will not only be stronger but will last longer. “The reason we think it could have advantages is because nalmefene is a drug itself [and] is stronger than naloxone. It’s five time stronger and it lasts longer,” Crystal told FOX Business.

    According to data released by the Centers for Disease Control and Prevention (CDC), fentanyl accounts for a significant portion of drug overdose deaths in the U.S. In 2016, opioids (prescription and illicit) accounted for 42,249 deaths out of total 63,632 drug overdose deaths in the U.S.

    The CDC also reported that “over half of people in 10 states who died of opioid overdoses during the second half of 2016 tested positive for fentanyl.”

    Crystal, who is working with the U.S. Health and Human Services Department, said they are aiming for FDA approval of Nasal Nalmefene by 2020.

    “Compounds like fentanyl, carfentanil and other synthetic opioids act for longer periods of time. The concern is that naloxone’s half-life doesn’t provide sufficient cover to prevailing amounts of fentanyl in the blood,” said Crystal in a past interview.

    Learn how to administer naloxone: How to Reverse an Opioid Overdose with Naloxone.

    View the original article at thefix.com

  • Narcan Administered At Record Pace In Boston

    Narcan Administered At Record Pace In Boston

    New city stats reveal that there were over 3,000 “narcotic-related illness” ambulance trips in 2017.

    In 2017, Boston’s first responders ran thousands of ambulance trips and administered Narcan for opioid overdoses in record numbers.

    New statistics revealed that Boston not only has a rising opioid epidemic in its own population, but that opioid use in the visiting population has risen alarmingly.

    According to the Boston Herald, Boston Emergency Medical Statistics revealed 3,557 “narcotic-related illness” ambulance trips to city hospitals in 2017—up from 2,848 in 2016.

    Twenty-nine percent of Boston’s narcotic-related ambulance trips were for patients who reported living outside Boston, EMS numbers show; this is a staggering 58% jump over 2016.

    Police and medical experts warn that 2018 could be just as bad with no signs that the drug epidemic is letting up. Boston police think it could be cheap heroin luring people with addiction to use in Boston.

    State police spokesman Dave Procopio told The Boston Herald that the drug fentanyl is increasingly laced into heroin to increase dealers’ profits.

    “Some users are actually seeking out fentanyl because it’s more potent,” said Procopio. He noted that the State Police Detective Unit for Suffolk County reported that a majority of current overdoses involved fentanyl.

    The Fix reported that some medical experts are seeking another avenue for reviving patients who have ingested fentanyl. The drug is so powerful that Narcan often does not work effectively.

    “Compounds like fentanyl, carfentanil, and other synthetic opioids act for longer periods of time,” said Dr. Roger Crystal, CEO of Opiant. “The concern is that naloxone’s half-life doesn’t provide sufficient cover to prevailing amounts of fentanyl in the blood.”

    Patients who overdosed with fentanyl in their system often have to receive multiple injections of Narcan over a period of time to be revived.

    Dr. Paul Biddinger, director of the Emergency Department at Massachusetts General Hospital in Boston, told The Boston Herald of the increasing number of Boston overdoses. “We don’t know what the cause is. The cost? Fentanyl? Unfortunately, it’s not going away for a while,” he said.

    The city of Boston reported that funds acquired to address the opioid epidemic are going to be put to use in the Boston Post-Overdose Response Team, or PORT. The program will be expanded and its hours increased.

    Paul Biddinger encourages “families, loved ones, even bystanders” to obtain and learn to use Narcan to save overdose victims.

    Of course treatment is necessary for recovery, but Narcan saves the person’s life so that they are here to participate in that recovery, he says.

    View the original article at thefix.com