Tag: opioid epidemic

  • Are Opioid Prescription Regulations Actually Working?

    Are Opioid Prescription Regulations Actually Working?

    New studies explored whether medical professionals are adhering to stricter opioid prescribing rules and regulations.

    While rules and regulations are often made in the interest of public safety, that doesn’t mean they are always followed hard and fast. 

    Such is the case with certain rules regarding opioid prescriptions, according to the Boston Globe. The paper states that according to the results of two studies published Wednesday (August 22) in the journal JAMA Surgery, “such well-intentioned efforts sometimes don’t have the desired effect.”

    The first study concluded that after one rule made it more difficult to refill the painkiller hydrocodone, surgeons began prescribing more of the medication right after surgery instead. 

    Meanwhile, the second study examined a regulation which required surgeons to check a database before prescribing opioids, the idea being that the database would alert them to patients at risk of opioid misuse.

    However, the study found that the procedure took up surgeons’ time but did not affect their prescribing practices in one New Hampshire hospital. 

    According to the Globe, both the studies were limited in terms of geographic area and only studying surgeon’s prescribing behaviors.

    Dr. Michael Barnett, a Harvard health-services researcher who studies opioid prescribing, tells the Globe that the results point to a bigger problem.

    “Clinician behavior is harder to predict, when you put these kinds of limits on it, than we’d like to think,” he said. “Regardless of the law you put in place, physicians are going to respond to what patients need… We need to ask a harder question: How do we influence health care decisions?”

    Prescribing practices have been under scrutiny for a number of years. In 2014, the Globe states, the U.S. Drug Enforcement Administration (DEA) changed hydrocodone from a Schedule III to a Schedule II drug, meaning patients would not be able to refill it over the phone.

    After that went into effect, researchers at the University of Michigan chose to study the effects on post-surgery prescribing. They looked at prescriptions for 21,955 patients who had had elective surgery in 75 Michigan hospitals from 2012 to 2015. Study authors found that prescription refills decreased, but the number of pills a patient left the hospital with increased.

    According to study author Dr. Michael Englesbe, the idea seemed to be that if doctors gave patients more prescriptions, they would be more likely to have the necessary pain relief and not seek more medication.

    However, Englesbe says, previous research indicates that “the number of pills you give someone has no relationship to their likelihood of calling for a refill. The more pills you give a patient, the more they take, and they don’t rate their pain care any better. It’s counterintuitive.”

    View the original article at thefix.com

  • Trump To Jeff Sessions: Sue Drug Companies For Opioid Crisis Role

    Trump To Jeff Sessions: Sue Drug Companies For Opioid Crisis Role

    The Attorney General said he would take action on Trump’s requests. 

    President Donald Trump has instructed Attorney General Jeff Sessions to file a federal lawsuit against pharmaceutical companies in Mexico and China, claiming that they have played a role in the US opioid epidemic.

    Last week, according to the New York Post, the president threw blame at China and Mexico for their roles in the opioid epidemic, claiming the countries had manufactured some of the illegal opioids coming into the United States.

    “In China, you have some pretty big companies sending that garbage and killing our people. It’s almost like a form of warfare. I’d like you to do what you can legally,” Trump said to Sessions.

    Fox News reports that Trump’s remarks came during a Cabinet meeting on Thursday, Aug. 16. Fox notes it was somewhat unusual that Trump asked for a new “major” lawsuit to be filed, rather than asking Sessions to join existing lawsuits filed by various US states. 

    “I’d also like to ask you to bring a major lawsuit against the drug companies on opioids,” Trump stated at the meeting, according to Fox. “Some states have done it, but I’d like a lawsuit to be brought against these companies that are really sending opioids at a level that — it really shouldn’t be happening. … People go into a hospital with a broken arm, they come out, they’re a drug addict.”

    Sessions said he would take action on Trump’s requests. 

    “We absolutely will,” Sessions said at the meeting. “We are returning indictments now against distributors from China; we’ve identified certain companies that are moving drugs from China, fentanyl in particular. We have confronted China about it … Most of it is going to Mexico and then crossing the border, unlawfully, from Mexico.”

    As of now, more than 25 US states have filed more than 1,000 lawsuits against opioid distributors and manufacturers.

    Last week, New York filed a lawsuit against Purdue Pharma, stating the manufacturer of the painkiller OxyContin has mislead medical professionals and patients about the dangers of the medication. Massachusetts also filed a lawsuit against the company in June, accusing the company of a “web of illegal deceit.” 

    According to recent estimates, overall overdose deaths in the US in 2017 were about 72,000 — an increase of 6,000 from 2016’s estimates.

    However, preliminary 2018 data implies that the “numbers may be trending downward in the wake of the Trump administration’s efforts to curb the epidemic.”

    View the original article at thefix.com

  • St. Louis Pushes To Expand Medication-Assisted Treatment For The Uninsured

    St. Louis Pushes To Expand Medication-Assisted Treatment For The Uninsured

    The city’s current healthcare program for the poor and uninsured does not cover mental health or addiction services.

    St. Louis officials are asking a federal agency to expand access to medication-assisted treatment under a program that provides healthcare services to uninsured individuals in the city.

    The Gateway to Better Health program, which is federally funded, serves uninsured St. Louis County residents who are living below the poverty line by providing basic health services at community health centers.

    Currently the program does not cover mental health or addiction services, but officials are asking the Centers for Medicare and Medicaid Services to allow the program to cover medication-assisted treatment with Suboxone and naltrexone.

    “We’re the first to admit there are major gaps, and one of our major gaps is mental health and substance abuse services,” Robert Freund, CEO of the St. Louis Regional Health Commission, which operates and monitors the program, told KBIA, Missouri’s NPR affiliate. “It’s only gotten worse as the opioid crisis has really escalated here in our region.”

    The Missouri Department of Health and Senior Services has asked the Centers for Medicare and Medicaid Services to reroute about $2 million currently allotted to the Gateway to Better Health program in order to allow community health centers to distribute Suboxone or naltrexone to people with opioid use disorder. The program would also require $750,000 in local matching funds, which has not been secured yet. 

    The program is also seeking approval to offer counseling, psychological testing and medication-assisted treatment for alcohol use disorder. 

    Freund said that if the community health centers are better able to serve people with substance use disorders, it would cut down on demand at clinics that only treat addiction, many of which are overwhelmed. 

    “We can increase access and decrease the burden on our substance abuse providers,” he said.

    Integrating care for substance use into a larger community center also allows people to seek help without judgement, said Kendra Holmes, the vice president of Affinia Healthcare, which operates community health centers in St. Louis.

    “I think it really helps with the stigma,” Holmes said. “Because you really don’t know what the patient is coming here for. If it were a separate entity, if we called it ‘Affinia Substance Abuse Center,’ there would be a stigma.”

    Affinia Healthcare currently has two providers trained to provide substance abuse treatment, who are paid for with grant money. Holmes said if the federal government approves the changes, Affinia would be able to offer addiction treatment services at more clinics. 

    Freund acknowledged that the requested changes “would be very limited in nature but still very helpful.”

    “We’re under no illusions this would solve our access issue for substance abuse in the eastern region,” he said. “However, it’s a start and it would help.”

    View the original article at thefix.com

  • Fentanyl Found In Startling Number Of Heroin Samples In Canada

    Fentanyl Found In Startling Number Of Heroin Samples In Canada

    “Something like 60% of the drugs that we check are not what people think they are,” said the author of a new drug-testing study.

    Drugs in Vancouver, Canada may be even more dangerous than normal, according to a new pilot project. 

    The project from the B.C. Centre on Substance Use (BCCSU) found that more than 80% of drugs sold as heroin in Vancouver do not actually contain heroin, but rather a dangerous synthetic opioid called fentanyl. 

    For the project, the BCCSU gave local users the opportunity to test their drugs for fentanyl as well as other substances. The study took place from November 2017 to April 2018 at two supervised-consumption sites in the Downtown Eastside part of Vancouver.

    In total, 1,714 samples were tested with fentanyl test strips and an infrared spectrometer. 

    The results, which the Globe and Mail reports will be published in September in the Drug and Alcohol Dependence journal, demonstrated that fentanyl was present in a great deal of local drugs, especially heroin. The project also found that types of drugs such as stimulants and hallucinogens are more likely to contain the substance they are sold as.

    The findings, according to co-author Mark Lysyshyn, give insight into how problematic the contamination of various drugs is locally. 

    “Something like 60% of the drugs that we check are not what people think they are,” Lysyshyn said on Tuesday, according to the Globe and Mail. “We’ve always had the idea that drugs could be something different, but right now [the contamination rate] is really high.”

    During the study, the Globe and Mail states, authors found that the majority of drug samples (58.7%) were expected to be opioids. They received 907 samples of what was thought to be heroin, but only 160 (17.6%) contained heroin. Of the total 907, 822 contained fentanyl. 

    Lysyshyn says the results aren’t necessarily indicative of the illegal drug market as a whole since the study was concentrated in downtown Vancouver. 

    He also added that the intention of the study was not to prove whether an illegal drug is safe, but instead to encourage those who use the drugs to seek out more information about what they are putting into their bodies. 

    “I don’t think the purpose of drug checking is to say, ‘These are safe; take them recklessly.’ That’s not what we’re trying to do,” he said, according to the Mail and Globe. “We’re saying, here’s a bit more information about these substances; they still could be risky. Because even if you find out there’s no fentanyl in your heroin, heroin causes overdoses, too. We don’t want people to forget all about the other harm-reduction advice that we’re giving; this is just additional information that we think could be helpful.”

    View the original article at thefix.com

  • More ERs Are Providing Withdrawal Meds As First Step To Recovery

    More ERs Are Providing Withdrawal Meds As First Step To Recovery

    Patients in need are receiving buprenorphine to address their withdrawal symptoms. 

    Kicking an opioid habit comes with a host of physical withdrawal symptoms so severe that people often end up in the emergency room.

    There, they are usually treated for diarrhea or vomiting, but not the underlying issue. Now, however, more emergency rooms around the county are providing buprenorphine to help ease withdrawal and get more people into treatment. 

    “With a single ER visit we can provide 24 to 48 hours of withdrawal suppression, as well as suppression of cravings,” Dr. Andrew Herring, an emergency medicine specialist at Highland Hospital in Oakland, California, told The New York Times

    At Highland, people who come in presenting with withdrawal symptoms are given a dose of buprenorphine, also known as Suboxone, and are told to follow up with Herring, who runs the hospital’s buprenorphine program. 

    “It can be this revelatory moment for people—even in the depth of crisis, in the middle of the night,” Herring said. “It shows them there’s a pathway back to feeling normal.”

    Although the Drug Enforcement Administration (DEA) requires doctors to receive special training and a license to prescribe buprenorphine, doctors in the ER can provide the medication without this training. Still, Herring said, many healthcare providers hesitate to provide the first step toward medication-assisted treatment (MAT). 

    “At first it seemed so alien and far-fetched,” he said. 

    Yet, research into the practice is promising. A 2015 study showed that people who were given buprenorphine in the ER were twice as likely to be in treatment 30 days later than those who were not given medication to help with withdrawal.  

    “I think we’re at the stage now where emergency docs are saying, ‘I’ve got to do something,’” said Dr. Gail D’Onofrio, lead study author. “They’re beyond thinking they can just be a revolving door.”

    California has plans to expand treatment for withdrawal in emergency rooms, using $78 million in federal funding to establish a hub-and-spoke system where people would get their first dose of medication in the emergency room before being connected with ongoing services.

    Dr. Kelly Pfeifer, director of high-value care at the California Health Care Foundation, said this is the next step in providing quality care for people fighting addiction. 

    “We don’t think twice about someone having a heart attack, getting stabilized in the emergency department, and then getting ongoing care from the cardiologist,” she said. “And the risk of death within a year after an overdose is greater than it is for a heart attack.”

    View the original article at thefix.com

  • Are Construction Workers Hit Hardest By Opioid Addiction?

    Are Construction Workers Hit Hardest By Opioid Addiction?

    A new survey examined the occupations of those who died from opioid-related causes. 

    It’s been considered a problem for years, and a new study in Massachusetts has proven that the construction industry is the worst affected from opioid-related overdose deaths. Architecture and engineering are the only careers with higher death rates among women than men.

    “The primary workforce in construction is male, and they’re twice as common to abuse prescription drugs than females,” Eric Goplerud told Forbes. Goplerud is senior vice president of the Department of Substance Abuse Mental Health and Criminal Justice Studies at NORC at the University of Chicago.

    Dezeen magazine reported that the Massachusetts Department of Public Health published a report on the opioid epidemic in a state that had opioid overdose deaths more than double between 2011 and 2015. The Opioid-Related Overdose Deaths in Massachusetts by Industry and Occupation survey reviewed death certificates from those years to compile data about industry and occupation, gender, race, and age among the deaths.

    Between 2011 and 2015, 5,580 Massachusetts residents died from opioid-related overdoses. Some of these deaths were excluded from the study.

    Construction and extraction workers were found to make up over 24% of the total, the highest amount of any particular profession. The analysis of the study authors believe this is due to the high amount of injuries people in this field endure. The report quotes a statistic that four out of every 100 construction workers are injured on site.

    “Pain is a common feature among injured workers and previous research indicates that opioids are frequently prescribed for pain management following work-related injuries, which has the potential to lead to opioid use disorders,” according to Dezeen. The study was first reported by the Architect’s Newspaper.

    According to experts interviewed in the Forbes piece, changing the construction company owners’ approach to opioid abuse is not going to be easy. Many (if not most) construction companies have a zero tolerance policy regarding positive drug tests of workers. If a worker tests positive, it often means he or she loses the job.

    “You go on construction sites, and you see those signs saying ‘you’re out of there if you test positive,’” Boston Properties Life Safety and Security Assistant Director John Tello told Forbes. “It seems like there is a divide in what’s going on and what needs to be done to help these people.”

    “Helping wean workers off opioids as they prepare to return to work should be part of any rehabilitation treatment,” Goplerud told Forbes.

    View the original article at thefix.com

  • Could Informing Doctors Of Patients' Opioid Deaths Curb Prescribing?

    Could Informing Doctors Of Patients' Opioid Deaths Curb Prescribing?

    How are doctors’ prescribing behavior affected when they’re notified of their own patients’ opioid-related deaths?

    Some California doctors have recently received letters that changed how they prescribed opioids, according to new research.

    The letters informed doctors of the deaths of patients to whom they had prescribed opioids, according to the Washington Post. Such letters were part of a study conducted by researchers at the University of Southern California and published Thursday (August 9) in the journal Science.

    The letters were sent by the San Diego County Medical Examiner Office to hundreds of doctors who, in the past year, had prescribed opioids to a patient who later died.

    “This is a courtesy communication to inform you that your patient [name, date of birth] died on [date]. Prescription drug overdose was either the primary cause of death or contributed to the death,” the letters read. “We hope that you will take this as an opportunity to join us in preventing future deaths from drug overdose.”

    According to the Post, the idea behind the study was to close the gap between a doctor’s care and a doctor’s knowledge about the potential consequences of prescribing opioids.

    While many doctors are aware that opioid use disorder is a widespread issue, they may believe that the consequences affect other doctors’ patients rather than their own, the Post noted. 

    According to the results of the study, doctors who learned of a patient’s death at the hands of opioids were 7% less likely to prescribe opioids to new patients. Doctors who received a letter also had a tendency to prescribe fewer high-dose prescriptions within the next three months  of receiving the letter. The total amount of opioids these doctors prescribed decreased by 9.7%. 

    “What’s particularly interesting to me is the personal nature of it,” Alexander Chiu, a surgeon at Yale New Haven Hospital who was not involved in the study, told the Post. “Depending on what field you’re in, [the opioid epidemic] can feel a little remote. If you’re not a pain doctor or a primary-care doctor, it’s not quite as common to know or see your actions having a negative impact, which is what this is showing—it makes it very real. As evidence-based as we are as a profession, sometimes anecdotes can be really powerful.”

    Lead researcher Jason Doctor, director of health informatics at the University of Southern California’s Schaeffer Center for Health Policy and Economics, tells the Post that while doctors have knowledge of facts, they are still human.

    “One of the takeaways I’d like people to have is that doctors learn a lot of clinical facts, but when it comes to clinical judgment and decision-making, they fall prey to the same biases that we all do,” he said. 

    According to Doctor, San Diego County plans to continue sending these letters, and other counties have also said they are interested in doing something similar.

    View the original article at thefix.com

  • Fentanyl, Other Synthetic Drugs Drive National Overdose Rates Up

    Fentanyl, Other Synthetic Drugs Drive National Overdose Rates Up

    Nearly 30,000 Americans died from overdoses stemming from fentanyl and other synthetic opioids in 2017.

    Driven in large part by widespread opioid use, the number of drug overdoses nationwide shot up nearly 10% last year, according to preliminary federal figures. 

    The U.S. clocked more than 72,000 drug fatalities in 2017, the Centers for Disease Control and Prevention (CDC) reported last week. That’s up by more than 6,000 from the 2016 figures, bringing the tally to nearly 200 deaths a day—more than the total number of gun, car crash or HIV deaths in any single year, ever. 

    But the new numbers—which represent a two-fold increase over 10 years ago—could actually be underestimating the true scope of the problem as full data from some states still isn’t in yet. 

    A big chunk of the increase—nearly 50,000 fatalities—comes from opioid deaths, a category that’s more than quadrupled since 2002. An increase in cocaine fatalities is also feeding into the higher figures. 

    Meanwhile heroin, painkiller, and methadone fatality figures have started to flatten out; it’s fentanyl deaths that are continuing to rise. Last year, close to 30,000 Americans died from overdoses stemming from fentanyl and other synthetic opioids.

    “Seventy-five percent of the deaths we get are fentanyl-related,”  Al Della Fave, a spokesman for the Ocean County, New Jersey prosecutor, told the Washington Post. “It’s the heroin laced with synthetic opioids that we’re getting creamed with.”

    The biggest increases are in some of the East Coast states already hardest hit by opioids, including Ohio, West Virginia and New Jersey. 

    In part, that’s due to the geography of drug-trafficking patterns. On the East Coast, heroin typically comes in a stronger powdered form—a form more easily mixed with deadly fentanyl. But in the western part of the country, cartels bring in black tar heroin from Mexico, which is both weaker and harder to mix with fentanyl. 

    “It is the 2.0 of drugs right now, the synthetics,” Tom Synan, the police chief in Newtown, Ohio, told the Post

    The current influx in opioid fatalities is commonly traced back to the 1990s, when drugmakers pushed addictive painkillers and doctors overprescribed them.

    Over a decade later, heroin took hold again when a cheap supply reshaped the market. But in recent years, it’s the introduction of fentanyl and other powerful synthetics that has driven the crisis to a deadlier point.

    And now that there’s finally been a downturn in some types of opioid fatalities, experts predict that any downward trend could be gradual given the nature of addiction and the stigma surrounding it.

    “Because it’s a drug epidemic as opposed to an infectious disease epidemic like Zika, the response is slower,” University of California San Francisco professor Dan Ciccarone told the New York Times. “Because of the forces of stigma, the population is reluctant to seek care. I wouldn’t expect a rapid downturn; I would expect a slow, smooth downturn.”

    View the original article at thefix.com

  • Experts Develop Post-Surgery Opioid Guidelines To Curb Overprescribing

    Experts Develop Post-Surgery Opioid Guidelines To Curb Overprescribing

    “Our feeling is we shouldn’t just be using draconian, one-size-fits all prescribing,” said one expert from Johns Hopkins. 

    Surgeons at Johns Hopkins Hospital in Baltimore have developed opioid prescribing guidelines that are specific to 20 common surgeries, in an effort to reduce overprescribing. 

    “This work reflects that surgeons want to be a part of the solution,” Dr. Heidi Overton, a surgery resident at Johns Hopkins who worked on the guidelines, told The Baltimore Sun.

    The guidelines were published this week in the Journal of the American College of Surgeons. Previously, Johns Hopkins doctors generally prescribed a 30-day supply of opioid painkillers following surgery, a standard that was “dangerously high,” according to lead study author Dr. Martin Makary, a professor of surgery and health policy expert at the Johns Hopkins University School of Medicine. 

    The new guidelines take into account what type of surgery a patient had. The panel that made the recommendations suggested one to 15 opioid pills for 11 of the 20 procedures, 16 to 20 pills for six of the 20 procedures, and none for three of the procedures—a drastic reduction from previous prescribing practices. 

    Patients having orthopedic surgeries needed the most opioid painkillers and those having ear, nose and throat procedures needed the fewest, study authors said. Doctors can adjust their prescription based on specific patients’ needs as well. 

    “Our feeling is we shouldn’t just be using draconian, one-size-fits all prescribing,” said Makary. “Everyone is different. Opioid prescribing should fall within a best practices range and currently we don’t do very well with that. Our hope is that this represents a first step in better understanding how we can treat pain better.”

    Makary noted that one in 16 surgery patients become long-term drug users. He also explained that more than half of patients who did not need opioids to manage pain in the hospital are still sent home with a prescription. Because of that, 70 to 80% of opioids prescribed to patients are never used as prescribed.

    Changing standards around opioid prescriptions is part of addressing the current overdose crisis, he said.  

    “We don’t just need treatment and rehab facilities,” Makary said. “We shouldn’t just be cleaning up the floor, but we should be turning off the spigot of overprescribing that doctors did with good intention, but bad science.”

    Other teaching hospitals have tried to implement opioid prescription guidelines, but the American College of Surgeons has not addressed the issue.

    However, the organization is putting together a brochure “to help surgeons facilitate a dialog with their patients on postoperative pain relief.”

    View the original article at thefix.com

  • Opioid Crisis Has Peaked, Former Cleveland Clinic CEO Suggests

    Opioid Crisis Has Peaked, Former Cleveland Clinic CEO Suggests

    The doctor says that while opioid prescribing is down, synthetic opioids are now driving the opioid epidemic.  

    The former CEO of the Cleveland Clinic said that the opioid epidemic has peaked now that more healthcare providers and laypeople are aware of the dangers of opioid painkillers.

    “I think we’ve peaked,” Dr. Toby Cosgrove said on CNBC’s Squawk Box. “I think we’re starting to see the understanding of the problem, and getting to the point where people are certainly prescribing fewer drugs and people are recognizing how serious this is.”

    However, he said that synthetic opioids are continuing to drive opioid deaths. 

    “The other issue is that drugs are now being laced with fentanyl and carfentanil, which are highly potent,” said Cosgrove, a cardiac surgeon who led the Cleveland Clinic hospital for 13 years before stepping down in 2017.

    “Carfentanil is 10,000 times as potent as morphine. We just had an outbreak of deaths in Ohio from drugs being laced with very potent carfentanil and fentanyl,” Cosgrove noted.

    Cosgrove now works as an executive advisor to Google Cloud Healthcare and Life Sciences team, and is a proponent for healthcare reform. During his CNBC appearance he talked about ways to reduce healthcare costs.

    He noted that while the United States has the highest healthcare costs in the world, the country is about average in the amount spent on healthcare and social programs combined. He said that this shows that investing in social programs can help alleviate the burden of healthcare costs. 

    “Social programs, frankly, are driving down the healthcare costs” in other countries, he said. 

    Although there has been some leveling of opioid overdose rates in certain areas, the national overdose rate climbed in many places between 2016 and 2017. In fact, 45 states saw opioid overdoses increase 30% between July 2016 and September 2017, according to federal data.

    During that time period, the Midwest—including the area served by the Cleveland Clinic—saw opioid overdose rates increase 70%, driven largely by an influx of synthetic opioids. In fact, fentanyl is a factor in nearly half of opioid-related deaths. 

    As Cosgrove suggested, opioid prescribing is down. However, this isn’t necessarily linked to a reduction in overdose deaths. In fact, West Virginia decreased the amount of opioids prescribed by 12% between 2016 and 2017, but still saw opioid-related overdose deaths rise. Because of this, some medical experts warn that the opioid crisis could continue to get worse before improving. 

    “I think we have to realize that we’re on a trajectory that may get a lot worse before it gets better,” said Donald S. Burke, dean of the University of Pittsburgh’s Graduate School of Public Health. 

    View the original article at thefix.com